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2006; 444 (7120):756–760. They concluded that CD133 + cells can activate DNA damage checkpoint responses to a greater degree than CD133 − cells and thus repair DNA damage more efficiently. Intriguingly, by using an inhibitor of the checkpoint kinases Chk1 and Chk2, they were able to radiosensitize the CD133 + cells. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Autores: Shideng Bao, Qing Shi, Yueling Hao, Roger E. McLendon, Darell D. Bigner, Qiulian Wu, Anita B. Hjelmeland, Jeremy N. Rich, Mark W. Dewhirst Add your e-mail address to receive free newsletters from SCIRP. In response to radiation, cells activate the DNA damage response (DDR), which initiates a series of cascades involving cell cycle checkpoint activation, various forms of DNA repair and, if unsuccessful, inducing apoptosis. GBMs are highly resistant to treatment for a number of reasons that will be discussed in more detail below.

Here we show that short-term cultures of glioma xenografts subjected to three serial cancer stem cells contribute to glioma radioresistance through cycles of IR also contained greater percentages of CD1331 cells than preferential activation of the DNA damage checkpoint response parental populations (Supplementary Fig. S2). Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Ionizing radiation represents the most effective therapy for glioblastoma (World Health Organization grade IV glioma), one of the most lethal human malignancies, but radiotherapy remains only palliative because of radioresistance. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JNGlioma stem cells promote radioresistance by preferential activation of the DNA damage response. cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour In response to radiation, cells activate the DNA damage response (DDR), which initiates a series of cascades involving cell cycle checkpoint activation, various forms of DNA repair and, if unsuccessful, inducing apoptosis. GBMs are highly resistant to treatment for a number of reasons that will be discussed in more detail below.

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Other groups also reported that the cancer stem cells of breast cancers were rela-tively resistant to radiation, potentially due to lower levels of reactive oxygen species found in cancer stem cells [14]. The emerging role of cancer stem cells in tumor Glioblastoma is an aggressive and heterogeneous tumor in which glioblastoma stem cells (GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance. The high entropy of GSCs is driven by a permissive epigenetic landscape and a mutational landscape that revokes crucial cellular checkpoints. In response to DNA damage, normal cells activate the DNA damage response (DDR), utilizing a variety of DNA damage sensing and repair pathways (e.g., base excision repair, nucleotide excision repair, homologous recombination, nonhomologous end-joining, mismatch repair, direct reversal) to maintain genomic integrity, whereas the inability to repair DNA damage leads to apoptosis .

Glioma stem cells promote radioresistance by preferential activation of the dna damage response

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Ionizing radiation represents the most effective therapy for glioblastoma (World Health Organization grade IV glioma), one of the most lethal human malignancies, but radiotherapy remains only palliative because of radioresistance. The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. cancer stem cells contribute to glioma radioresistance through cycles of IR also contained greater percentages of CD1331 cells than preferential activation of the DNA damage checkpoint response parental populations (Supplementary Fig. S2). Thus, tumours sur- Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. We have examined DNA repair in five stem and nonstem glioma cell lines. The population doubling time was … Comparative analysis of DNA repair in stem and nonstem glioma cell cultures.

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. Mol Cancer 2006;5:67.
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cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. Nature. 2006 Dec 7;444(7120):756-60. Epub 2006 Oct 18.

Autores: Shideng Bao, Qing Shi, Yueling Hao, Roger E. McLendon, Darell D. Bigner, Qiulian Wu, Anita B. Hjelmeland, Jeremy N. Rich, Mark W. Dewhirst Add your e-mail address to receive free newsletters from SCIRP.
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The fraction of tumour Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. Nature. 2006 Dec 7;444(7120):756-60. Epub 2006 Oct 18.

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The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. cancer stem cells contribute to glioma radioresistance through cycles of IR also contained greater percentages of CD1331 cells than preferential activation of the DNA damage checkpoint response parental populations (Supplementary Fig. S2). Thus, tumours sur- Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction It has been reported that cancer stem cells may contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity.